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艾伐卡托

Tier B — Position early

Ivacaftor

Vertex Pharmaceuticals Incorporated
Originator
2012
First approval
-
Expiry (public)
$1.01B ▲
Peak sales
化学药
Type

Targets：CFTR

Brand：Kalydeco

Indications (approved)：囊性纤维化

Regional status

US
批准上市
2012-01-31
EU
批准上市
2012-07-22
China
-
Japan
-

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 8 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
IVAC-00162-53-3aniline
IVAC-00287-13-8diethyl 2-(ethoxymethylene)malonate
IVAC-00354535-22-7diethyl 2-((phenylamino)methylene)malonate
IVAC-00452980-28-6ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
IVAC-00513721-01-24-oxo-1,4-dihydroquinoline-3-carboxylic acid
IVAC-006873055-58-45-amino-2,4-di-tert-butylphenol
IVAC-00796-76-42,4-di-tert-butylphenol
IVAC-008873055-54-02,4-di-tert-butylphenyl methyl carbonate
IVAC-009873055-55-12,4-di-tert-butyl-5-nitrophenyl methyl carbonate
IVAC-010873055-57-32,4-di-tert-butyl-5-nitrophenol
OptimisedRoute 2Steps 5 · Total yield 8.06 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
IVAC-00796-76-42,4-di-tert-butylphenol
IVAC-011541-41-3ethyl carbonochloridate
IVAC-0121430836-75-12,4-di-tert-butylphenyl ethyl carbonate
IVAC-0131430836-76-22,4-di-tert-butyl-5-nitrophenyl ethyl carbonate
IVAC-0141430836-77-35-amino-2,4-di-tert-butylphenyl ethyl carbonate
IVAC-01580761-61-14-oxo-1,4-dihydroquinoline-3-carbonyl chloride
IVAC-0161430836-78-42,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl ethyl carbonate
OptimisedRoute 3Steps 6 · Total yield 436 mg
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
IVAC-017610-14-02-nitrobenzoyl chloride
IVAC-018106718-56-3diethyl 2-(2-nitrobenzoyl)malonate
IVAC-01952119-39-8ethyl 3-(2-nitrophenyl)-3-oxopropanoate
IVAC-0201182822-31-65-amino-2,4-di-tert-butylphenyl methyl carbonate
IVAC-0211624596-06-02,4-di-tert-butyl-5-(3-(2-nitrophenyl)-3-oxopropanamido)phenyl methyl carbonate
IVAC-0221624596-07-12,4-di-tert-butyl-5-(3-(dimethylamino)-2-(2-nitrobenzoyl)acrylamido)phenyl methyl carbonate
IVAC-0231246213-45-52,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate
OptimisedRoute 4Steps 6 · Total yield 44 mg
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
IVAC-0201182822-31-65-amino-2,4-di-tert-butylphenyl methyl carbonate
IVAC-0231246213-45-52,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate
IVAC-02434846-90-7Availablemethyl (E)-3-methoxyacrylate
IVAC-02560778-73-6(E)-3-methoxyacryloyl chloride
IVAC-0261624596-02-6(E)-2,4-di-tert-butyl-5-(3-methoxyacrylamido)phenyl methyl carbonate
IVAC-0271624596-03-7(E)-2,4-di-tert-butyl-5-(3-morpholinoacrylamido)phenyl methyl carbonate
IVAC-028134-20-3methyl 2-aminobenzoate
IVAC-0291624596-05-9methyl (E)-2-((3-((2,4-di-tert-butyl-5-((methoxycarbonyl)oxy)phenyl)amino)-3-oxoprop-1-en-1-yl)amino)benzoate
OptimisedRoute 5Steps 5 · Total yield 15.8 g
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
IVAC-00452980-28-6ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
IVAC-00796-76-42,4-di-tert-butylphenol
IVAC-010873055-57-32,4-di-tert-butyl-5-nitrophenol
IVAC-0301610595-14-61-(benzyloxy)-2,4-di-tert-butyl-5-nitrobenzene
IVAC-0311610595-15-75-(benzyloxy)-2,4-di-tert-butylaniline
IVAC-0321610595-16-8N-(5-(benzyloxy)-2,4-di-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Frequently asked questions

What are the approved indications of Ivacaftor?

Approved indications include: 囊性纤维化.

When does the Ivacaftor patent expire?

No public expiry year is available for Ivacaftor yet; this page updates once verified.

How many synthesis routes are recorded for Ivacaftor?

5 synthesis routes are recorded; the shortest is 5 steps with 8.06 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ivacaftor intermediates?

1 intermediate CAS of Ivacaftor are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ivacaftor intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24