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CAS 1195768-20-7
N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Codes：DABF-011
Application context (from source-drug indications)
甲状腺瘤甲磺酸达拉非尼结直肠癌甲磺酸达拉非尼胶质瘤甲磺酸达拉非尼甲状腺未分化癌甲磺酸达拉非尼实体瘤甲磺酸达拉非尼非小细胞肺癌甲磺酸达拉非尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 甲磺酸达拉非尼Dabrafenib Mesylate | Tier B — Position early | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,6-difluorobenzene-1-sulfonyl chloride→2,2-dimethylpropanethioamide→methyl 3-amino-2-fluorobenzoate→methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate→2-chloro-4-methylpyrimidine→N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-(tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 2,6-Difluorobenzenesulfonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Methyl 3-amino-2-fluorobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | Methyl 3-(2,6-difluorophenylsulfonaMido) -2-fluorobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 2-chloro-4-methylpyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 2,2,2-Trimethylthioacetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.