CAS 60230-36-6

2,6-difluorobenzene-1-sulfonyl chloride

Codes：DABF-002

Application context (from source-drug indications)

甲状腺瘤甲磺酸达拉非尼结直肠癌甲磺酸达拉非尼胶质瘤甲磺酸达拉非尼甲状腺未分化癌甲磺酸达拉非尼实体瘤甲磺酸达拉非尼非小细胞肺癌甲磺酸达拉非尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲磺酸达拉非尼Dabrafenib Mesylate	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

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甲磺酸达拉非尼优化路线steps: 5total yield: 3.58 g

ethyl 3-(3-amino-2-fluorophenyl)-3-oxopropanoate→2,6-difluorobenzene-1-sulfonyl chloride→ethyl 3-(3-(2,6-difluorophenylsulfonamido)-2-fluorophenyl)-3-oxopropanoate→2,2-dimethylpropanethioamide→ethyl 2-(tert-butyl)-4-(3-(2,6-difluorophenylsulfonamido)-2-fluorophenyl)thiazole-5-carboxylate→N-(3-(5-acetyl-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

甲磺酸达拉非尼原研路线steps: 6total yield: 2.39 g

2,6-difluorobenzene-1-sulfonyl chloride→2,2-dimethylpropanethioamide→methyl 3-amino-2-fluorobenzoate→methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate→2-chloro-4-methylpyrimidine→N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide→N-(3-(2-(tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	2,6-Difluorobenzenesulfonyl chloride Pharmaceutical Intermediates	询价	询价	询价	—

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