CAS 120-29-6

3-Tropanol

Codes：Tropisetron- 002

Application context (from source-drug indications)

化疗导致的恶心和呕吐枸橼酸托烷司琼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
枸橼酸托烷司琼Tropisetron Citrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

枸橼酸托烷司琼优化路线steps: 1total yield: /

1H-Indole-3-carbonyl chloride→3-Tropanol

枸橼酸托烷司琼优化路线steps: 1total yield: 29.1g(Tropisetron)

3-Indole formic acid→3-Tropanol

枸橼酸托烷司琼优化路线steps: 2total yield: 28.3g(Tropisetron)

3-Indolylcarboxylic acid→3-Tropanol

枸橼酸托烷司琼优化路线steps: 2total yield: 90.5g(Tropisetron- 004)

(1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate hydrogen chloride→3-Tropanol→3-Carboxyindole→1H-Indole-3-carbonyl chloride

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