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CAS 123161-41-1
ethyl 4-(1-(benzhydryloxy)-3-hydroxy-1-oxopropan-2-yl)-2,3,5-trifluorobenzoate
Codes: PAZU-005
Application context (from source-drug indications)
肺炎链球菌感染Pazufloxacin MesylateSepsisPazufloxacin MesylateInfectious diseasePazufloxacin MesylateCystitisPazufloxacin Mesylate胆管炎Pazufloxacin MesylateCholecystitisPazufloxacin Mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pazufloxacin Mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 2,3,4,5-tetrafluorobenzoate→di-tert-butyl malonate→2-(4-(ethoxycarbonyl)-2,3,6-trifluorophenyl)acetic acid→ethyl 4-(2-(benzhydryloxy)-2-oxoethyl)-2,3,5-trifluorobenzoate→ethyl 4-(1-(benzhydryloxy)-3-hydroxy-1-oxopropan-2-yl)-2,3,5-trifluorobenzoate→ethyl 4-(3-(benzhydryloxy)-3-oxoprop-1-en-2-yl)-2,3,5-trifluorobenzoate→ethyl 4-(1-((benzhydryloxy)carbonyl)cyclopropyl)-2,3,5-trifluorobenzoate→1-(4-(ethoxycarbonyl)-2,3,6-trifluorophenyl)cyclopropane-1-carboxylic acid→ethyl 4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoate→4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoic acid→3-ethoxy-3-oxopropanoic acid→CAS→(S)-2-aminopropan-1-ol→ethyl (S,Z)-2-(4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoyl)-3-((1-hydroxypropan-2-yl)amino)acrylate→ethyl (S)-10-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate→(S)-10-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid→(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
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