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CAS 1244-58-2

(1'R,2'R)-2,6-dihydroxy-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-3-carboxylic acid

Codes:CANN-001

Application context (from source-drug indications)

结节性脑硬化大麻二酚Dravet综合征大麻二酚Lennox Gastaut综合征大麻二酚精神病大麻二酚Ⅲ型黏多糖贮积症大麻二酚系统性硬皮病大麻二酚

Source drugs (routes using this intermediate)

DrugTierExpiry
大麻二酚CannabidiolTier B — Position early-

Position in synthesis routes (up/downstream chain)

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大麻二酚原研路线steps: 3total yield: 17.00-19.00 g
(1'R,2'R)-2,6-dihydroxy-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-3-carboxylic acid→(1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol→3,5-dinitrobenzoyl chloride→(1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diyl bis(3,5-dinitrobenzoate)

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