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CAS 124750-67-0

4'-((2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile

Codes:ALIS-010

Application context (from source-drug indications)

高血压阿利沙坦酯

Source drugs (routes using this intermediate)

DrugTierExpiry
阿利沙坦酯Allisartan IsoproxilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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阿利沙坦酯优化路线steps: 4total yield: 1.78 g
2-butyl-4-chloro-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carbaldehyde→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→2-butyl-4-chloro-1H-imidazole-5-carbaldehyde→4'-((2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→2-butyl-4-chloro-1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid→((isopropoxycarbonyl)oxy)methyl 2-butyl-4-chloro-1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate

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