CAS 13040-21-6

N-(3-hydroxyphenyl)acrylamide

Codes：OLMU-011

Application context (from source-drug indications)

非小细胞肺癌奥莫替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
奥莫替尼Olmutinib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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奥莫替尼优化路线steps: 2total yield: 50.6 g (Olmutinib)

2,4-dichlorothieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(3-hydroxyphenyl)acrylamide→N-(3-((2-chlorothieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

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