CAS 136794-87-1

Methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

Codes：18F-FP-CIT-005

Application context (from source-drug indications)

帕金森病18F-FP-CIT

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
18F-FP-CIT18F-FP-CIT	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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18F-FP-CIT优化路线steps: 4total yield: /

Trimethylene bromohydrin→3-Bromopropyl 4-methylbenzenesulfonate→1-Bromo-3-[18F]fluoropropane→3-[18F]Fluoropropyl trifluoromethanesulfonate→Methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

18F-FP-CIT优化路线steps: 2total yield: 13.15-11.14mg(18F-FP-CIT (Free))

1,3-Dibromopropane→1-Bromo-3-[18F]fluoropropane→Methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate

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