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CAS 137863-89-9
(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate
Codes：VALS-005
Application context (from source-drug indications)
高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压缬沙坦/氨氯地平乳清酸盐原发性高血压缬沙坦/盐酸乐卡地平
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 苯磺酸左旋氨氯地平/缬沙坦Levamlodipine Besylate/Valsartan | Tier C — Watch / trade | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
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