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CAS 638-29-9
pentanoyl chloride
Codes：IRBE-023、VALS-006
Application context (from source-drug indications)
高血压Atorvastatin Calcium Hydrate/Irbesartan高脂血症Atorvastatin Calcium Hydrate/Irbesartan高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压缬沙坦/氨氯地平乳清酸盐原发性高血压缬沙坦/盐酸乐卡地平高血压厄贝沙坦/三氯噻嗪
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atorvastatin Calcium Hydrate/IrbesartanAtorvastatin Calcium Hydrate/Irbesartan | Tier C — Watch / trade | - |
| 苯磺酸左旋氨氯地平/缬沙坦Levamlodipine Besylate/Valsartan | Tier C — Watch / trade | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| 厄贝沙坦/三氯噻嗪Irbesartan/Trichlormethiazide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-aminocyclopentane-1-carboxamide→pentanoyl chloride→1-pentanamidocyclopentane-1-carboxamide→N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentane-1-carboxamide
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-pentanamidocyclopentane-1-carboxylic acid→pentanoyl chloride→cyclopentanone→1-aminocyclopentane-1-carbonitrile→1-aminocyclopentane-1-carboxylic acid hydrochloride→4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
methyl L-valinate hydrochloride→pentanoyl chloride→1-bromo-4-(bromomethyl)benzene→(S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate→(S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid→(S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
methyl L-valinate hydrochloride→pentanoyl chloride→1-bromo-4-(bromomethyl)benzene→(S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate→(S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid→(S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
methyl L-valinate hydrochloride→pentanoyl chloride→1-bromo-4-(bromomethyl)benzene→(S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate→(S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid→(S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-aminocyclopentane-1-carboxamide→pentanoyl chloride→1-pentanamidocyclopentane-1-carboxamide→N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentane-1-carboxamide
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-pentanamidocyclopentane-1-carboxylic acid→pentanoyl chloride→cyclopentanone→1-aminocyclopentane-1-carbonitrile→1-aminocyclopentane-1-carboxylic acid hydrochloride→4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile
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