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CAS 141700-34-7
(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-17-(2-(isobutyryloxy)acetyl)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-16,17-diyl bis(2-methylpropanoate)
Codes: CICL-003
Application context (from source-drug indications)
AsthmaCiclesonidePerennial allergic rhinitisCiclesonideSeasonal allergic rhinitisCiclesonideAllergic rhinitisCiclesonide支气管肺发育不良CiclesonideCOVID-19Ciclesonide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ciclesonide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one→isobutyric anhydride→(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-17-(2-(isobutyryloxy)acetyl)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-16,17-diyl bis(2-methylpropanoate)→cyclohexanecarbaldehyde→2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl isobutyrate
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