Ciclesonide

Tier C — Watch / trade

Ciclesonide

Takeda Pharmaceutical Company Limited

Originator

2004

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：GR

Brand：Omnaris, Omnaris HFA, Omnair, Osonase, Zetonna, Alvesco, Osonide, Zetonna/Omnaris/Alvesco, Alvesco HFA

Indications (approved)：Asthma, Perennial allergic rhinitis, Seasonal allergic rhinitis, Allergic rhinitis

Regional status

Approved

2006-10-20

No progress

2002-04-01

China

Approved

2012-12-11

Japan

Approved

2007-04-18

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield /

CICL-00113951-70-7CICL-00297-72-3CICL-003141700-34-7CICL-0042043-61-0CICL-005204444-45-1API · Ciclesonide

Code	CAS No.	Intermediate
CICL-001	13951-70-7	(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CICL-002	97-72-3	isobutyric anhydride
CICL-003	141700-34-7	(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-17-(2-(isobutyryloxy)acetyl)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-16,17-diyl bis(2-methylpropanoate)
CICL-004	2043-61-0	cyclohexanecarbaldehyde
CICL-005	204444-45-1	2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl isobutyrate

OptimisedRoute 2Steps 2 · Total yield /

CICL-00297-72-3CICL-0042043-61-0CICL-006638-94-8CICL-00778806-61-8API · Ciclesonide

Code	CAS No.	Intermediate
CICL-002	97-72-3	isobutyric anhydride
CICL-004	2043-61-0	cyclohexanecarbaldehyde
CICL-006	638-94-8	(6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
CICL-007	78806-61-8	2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl isobutyrate

OptimisedRoute 3Steps 4 · Total yield 3.2 g

CICL-00113951-70-7CICL-00297-72-3CICL-0042043-61-0CICL-008—CICL-0091015172-34-5CICL-010161115-59-9API · Ciclesonide

Code	CAS No.	Intermediate
CICL-001	13951-70-7	(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CICL-002	97-72-3	isobutyric anhydride
CICL-004	2043-61-0	cyclohexanecarbaldehyde
CICL-008	-	(6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
CICL-009	1015172-34-5	2-((6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
CICL-010	161115-59-9	(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one

OptimisedRoute 4Steps 2 · Total yield 18 g

CICL-0042043-61-0CICL-011—CICL-0121451396-66-9CICL-013996-30-5API · Ciclesonide

Code	CAS No.	Intermediate
CICL-004	2043-61-0	cyclohexanecarbaldehyde
CICL-011	-	(8S,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-13-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CICL-012	1451396-66-9	(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-8b-(2-bromoacetyl)-10-cyclohexyl-7-hydroxy-6a,8a-dimethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
CICL-013	996-30-5	sodium isobutyrate

OptimisedRoute 5Steps 3 · Total yield /

CICL-0042043-61-0CICL-010161115-59-9CICL-011—CICL-01436609-97-9CICL-01579-30-1API · Ciclesonide

Code	CAS No.	Intermediate
CICL-004	2043-61-0	cyclohexanecarbaldehyde
CICL-010	161115-59-9	(6aR,6bS,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-cyclohexyl-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
CICL-011	-	(8S,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-13-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CICL-014	36609-97-9	sodium cyclohexyl(hydroxy)methanesulfonate
CICL-015	79-30-1	isobutyryl chloride

Frequently asked questions

What are the approved indications of Ciclesonide?

Approved indications include: Asthma, Perennial allergic rhinitis, Seasonal allergic rhinitis, Allergic rhinitis.

When does the Ciclesonide patent expire?

No public expiry year is available for Ciclesonide yet; this page updates once verified.

How many synthesis routes are recorded for Ciclesonide?

5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ciclesonide intermediates?

All intermediates in Ciclesonide routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Ciclesonide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27