CAS 141942-84-9

4-Cyano-3(R)-hydroxybutyric acid methyl ester

Codes：Atorvastatin-058

Application context (from source-drug indications)

高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
阿托伐他汀锶Atorvastatin strontium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀锶优化路线steps: 4total yield: 41.5g(Atorvastatin-047)

4-Cyano-3(R)-hydroxybutyric acid methyl ester→3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester→(3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-4-cyanobutanoic acid→3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentanenitrile→5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol

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