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阿托伐他汀锶
Tier C — Watch / tradeAtorvastatin strontium
韩美药品株式会社
Originator
2008
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：HMGCR
Brand：Newvast
Indications (approved)：高脂血症
Regional status
US
终止
2022-09-30
EU
-
China
临床三期
2024-09-01
Japan
-
Synthetic routes & intermediates20 routes
Originator routes × 0Optimised (non-patent) × 20Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 10 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-001 | - | [14C]-Sodium acetate |
| Atorvastatin-002 | 88-95-9 | ortho-Phthaloyl chloride |
| Atorvastatin-003 | - | [14C=O]Acetyl chloride |
| Atorvastatin-004 | 108998-83-0 | (2S)-1,1,2-Triphenylethane-1,2-diol |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-006 | 222406-66-8 | (1S)-2-hydroxy-1,2,2-triphenylethyl acetate |
| Atorvastatin-007 | 110862-46-9 | 5-(4-Fluorophenyl)-1-(3-oxopropyl)-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide |
| Atorvastatin-008 | 222406-69-1 | (1S)-2-hydroxy-1,2,2-triphenylethyl (3R)-5-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3-hydroxypentanoate |
| Atorvastatin-009 | 222406-71-5 | methyl (3R)-5-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3-hydroxypentanoate |
| Atorvastatin-010 | 222406-73-7 | tert-butyl (5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate |
| Atorvastatin-011 | 134395-00-9 | Atorvastatin tert-butyl ester |
| Atorvastatin-012 | 793652-69-4 | (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid |
| Atorvastatin-013 | 222406-80-6 | 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-014 | - | sodium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate |
OptimisedRoute 2Steps 7 · Total yield 1.21kg(Atorvastatin Strontium)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
| Atorvastatin-016 | - | Methyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-018 | 1353049-81-6 | Methyl [(4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-019 | - | (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-020 | - | Methyl (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate |
| Atorvastatin-021 | - | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3(R),5(R)-dihydroxyheptanoic acid sodium salt |
| Atorvastatin-011 | 134395-00-9 | Atorvastatin tert-butyl ester |
OptimisedRoute 3Steps 11 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-022 | 838906-36-8 | 4-(Benzyloxy)dihydro-2H-pyran-2,6(3H)-dione |
| Atorvastatin-023 | - | 3-Hydroxypentanedioic acid 1,5-diethyl ester |
| Atorvastatin-024 | 838906-52-8 | Diethyl 3-(benzyloxy)pentanedioate |
| Atorvastatin-025 | 1404189-41-8 | 3-(Benzyloxy)pentanedioic acid |
| Atorvastatin-026 | 112904-69-5 | (3R)-3-(Benzyloxy)-5-methoxy-5-oxopentanoic acid |
| Atorvastatin-027 | - | (Methoxycarbonyl)acetonitrile |
| Atorvastatin-028 | 1443774-74-0 | Dimethyl (5R)-5-(benzyloxy)-2-cyano-3-oxoheptanedioate |
| Atorvastatin-029 | 1443774-76-2 | Methyl (3R)-3-(benzyloxy)-6-cyano-5-oxohexanoate |
| Atorvastatin-030 | 1417187-90-6 | Methyl (3R)-6-cyano-3-hydroxy-5-oxohexanoate |
| Atorvastatin-031 | 676260-68-7 | Methyl (3R,5R)-6-cyano-3,5-dihydroxyhexanoate |
| Atorvastatin-032 | 714963-28-7 | Methyl [(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-033 | - | - |
| Atorvastatin-016 | - | Methyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
OptimisedRoute 4Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-034 | 65564-05-8 | Benzyl (3-oxopropyl)carbamate |
| Atorvastatin-035 | 75-07-0 | Ethanal |
| Atorvastatin-036 | 916852-78-3 | Benzyl [2-[(2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl]ethyl]carbamate |
| Atorvastatin-037 | 916852-79-4 | Benzyl [2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]carbamate |
| Atorvastatin-038 | 676260-70-1 | (4R,6R)-6-(2-aminoethyl)-4-hydroxyoxan-2-one |
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
OptimisedRoute 5Steps 1 · Total yield 50.7g(Atorvastatin Strontium)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
OptimisedRoute 6Steps 7 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-040 | 42558-54-3 | 4-Methyl-3-oxopentanoic acid methyl ester |
| Atorvastatin-041 | 1146977-84-5 | 4-Methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-042 | 100-52-7Available | Benzaldehyde |
| Atorvastatin-043 | - | 2-Benzylidene-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-044 | 1146977-88-9 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid |
| Atorvastatin-045 | - | (4-Fluorophenyl)methanone |
| Atorvastatin-046 | 1146977-86-7 | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-047 | 1146977-83-4 | 5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol |
| Atorvastatin-048 | 1146977-87-8 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid 4-methoxybenzyl ester |
| Atorvastatin-049 | 62-53-3 | Aminobenzene |
| Atorvastatin-050 | 1146977-89-0 | 1-[3(R)-[tert-butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-051 | 1146978-02-0 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
OptimisedRoute 7Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-052 | 98684-92-5 | 2-Ethoxy-2-oxoethanediazonium |
| Atorvastatin-053 | 1146977-91-4 | 5(R)-[tert-Butyl(dimethyl)silyloxy]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3-oxoheptanoic acid ethyl ester |
| Atorvastatin-054 | 1146977-92-5 | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-5(R)-hydroxy-3-oxoheptanoic acid ethyl ester |
| Atorvastatin-055 | 1146977-93-6 | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3(R),5(R)-dihydroxyheptanoic acid ethyl ester |
| Atorvastatin-056 | 616201-27-5 | Ethyl [(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-057 | 134523-07-2 | 5-(4-Fluorophenyl)-1-[2-[4(S)-hydroxy-6-oxotetrahydropyran-2(S)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-051 | 1146978-02-0 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
OptimisedRoute 8Steps 4 · Total yield 41.5g(Atorvastatin-047)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-058 | 141942-84-9 | 4-Cyano-3(R)-hydroxybutyric acid methyl ester |
| Atorvastatin-059 | 105876-27-5 | 3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester |
| Atorvastatin-060 | 105876-28-6 | (3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-4-cyanobutanoic acid |
| Atorvastatin-061 | 1146977-82-3 | 3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentanenitrile |
| Atorvastatin-047 | 1146977-83-4 | 5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol |
OptimisedRoute 9Steps 11 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-062 | - | (3aR,5S,6S,6aR)-5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol |
| Atorvastatin-063 | 80667-81-8 | 1,2:5,6-Di-O-isopropylidene-3-O-(imidazol-1-ylsulfonyl)-alpha-D-glucofuranose |
| Atorvastatin-064 | 21870-79-1 | 3-S-Acetyl-1,2:5,6-Di-O-isopropylidene-3-thio-alpha-D-allofuranose |
| Atorvastatin-065 | 4613-62-1 | 3-Deoxy-1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hexofuranose |
| Atorvastatin-066 | 1092527-73-5 | (3aR,5R,6aR)-2,2-Dimethyl-5-(2-nitroethyl)perhydrofuro[2,3-d][1,3]dioxole |
| Atorvastatin-067 | 4494-96-6 | 3-Deoxy-1,2-O-isopropylidene-alpha-D-ribo-hexofuranose |
| Atorvastatin-068 | - | (3aR,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde |
| Atorvastatin-069 | - | 1-[(3aR,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]-2-nitroethanol |
| Atorvastatin-070 | - | (3aR,6aR)-2,2-Dimethyl-5-(2-nitrovinyl)perhydrofuro[2,3-d][1,3]dioxole |
| Atorvastatin-071 | 1092527-75-7 | 2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethylamine |
| Atorvastatin-072 | 1092527-77-9 | 1-[2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-073 | - | 1-[2-[4(R),5-Dihydroxytetrahydrofuran-2(R)-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
OptimisedRoute 10Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-074 | - | Ethyl (diethoxyphosphoryl)acetate |
| Atorvastatin-075 | 896110-02-4 | 3-[(3aR,5S,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]-2-propenoic acid ethyl ester |
| Atorvastatin-076 | 1092527-64-4 | 3-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]propionic acid ethyl ester |
| Atorvastatin-077 | 1092527-66-6 | 3-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]propionamide |
| Atorvastatin-078 | 1092527-68-8 | 1,2-O-Isopropylidene-6-(methoxycarbonylamino)-3,5,6-trideoxy-alpha-D-erythro-hexofuranose |
| Atorvastatin-068 | - | (3aR,5S,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde |
| Atorvastatin-071 | 1092527-75-7 | 2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethylamine |
OptimisedRoute 11Steps 11 · Total yield 232.6g(Atorvastatin-017)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-079 | - | (2R)-2-(Chloromethyl)oxirane |
| Atorvastatin-080 | - | - |
| Atorvastatin-081 | 1370478-50-4 | (2R)-1-Chloro-4-nitrobutan-2-ol |
| Atorvastatin-082 | 1192308-67-0 | (3R)-3-Hydroxy-5-nitropentanenitrile |
| Atorvastatin-083 | - | 1-Methoxy-1-methylethyl methyl ether |
| Atorvastatin-084 | - | (2-(tert-Butoxy)-2-oxoethyl)zinc(II) bromide |
| Atorvastatin-085 | - | 1,1-Dimethylethyl monobromoacetate |
| Atorvastatin-086 | 1011476-83-7 | tert-Butyl (5R)-5-hydroxy-7-nitro-3-oxoheptanoate |
| Atorvastatin-087 | 1370478-51-5 | 3(R),5(R)-Dihydroxy-7-nitroheptanoic acid tert-butyl ester |
| Atorvastatin-088 | 619261-21-1 | tert-Butyl [(4R,6R)-2,2-dimethyl-6-(2-nitroethyl)-1,3-dioxan-4-yl]acetate |
| Atorvastatin-089 | - | Ethyl (3S)-4-bromo-3-hydroxybutanoate |
| Atorvastatin-090 | 154026-96-7 | tert-Butyl (5S)-6-bromo-5-hydroxy-3-oxohexanoate |
| Atorvastatin-091 | 154026-97-8 | tert-Butyl (3R,5S)-6-bromo-3,5-dihydroxyhexanoate |
| Atorvastatin-092 | 154026-98-9 | tert-Butyl [(4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-005 | - | 1,1-Dimethylethyl acetate |
OptimisedRoute 12Steps 15 · Total yield 3.83g(Atorvastatin-017)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-093 | 181272-46-8 | (3R)-3-Hydroxyhex-5-enenitrile |
| Atorvastatin-094 | 3536-96-7 | Chlorido(ethenyl)magnesium |
| Atorvastatin-095 | - | (2R)-1-Chloropent-4-en-2-ol |
| Atorvastatin-096 | 1622324-73-5 | (3R)-3-[(Trimethylsilyl)oxy]hex-5-enenitrile |
| Atorvastatin-097 | 950513-91-4 | tert-Butyl (5R)-5-hydroxy-3-oxooct-7-enoate |
| Atorvastatin-098 | 1622324-77-9 | tert-Butyl [(4R,6R)-6-[(2E)-2-(hydroxyimino)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-099 | 1622324-74-6 | tert-Butyl (3R,5R)-3,5-dihydroxyoct-7-enoate |
| Atorvastatin-100 | 1622324-75-7 | tert-Butyl [(4R,6R)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-101 | 1622324-76-8 | tert-Butyl [(4R,6S)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]acetate |
| Atorvastatin-102 | - | Hydroxylamine hydrochloric acid |
| Atorvastatin-103 | 1173184-84-3 | (4R)-2,2-Dimethyl-6beta-(2-hydroxyethyl)-1,3-dioxane-4beta-acetic acid tert-butyl ester |
| Atorvastatin-104 | 1380521-21-0 | tert-Butyl [(4R,6R)-6-[2-[(methanesulfonyl)oxy]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-105 | 682356-88-3 | tert-Butyl [(4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-079 | 51594-55-9 | (2R)-2-(Chloromethyl)oxirane |
| Atorvastatin-083 | - | 1-Methoxy-1-methylethyl methyl ether |
| Atorvastatin-085 | - | 1,1-Dimethylethyl monobromoacetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-040 | - | Methyl (3R)-3-hydroxyhex-5-enoate |
OptimisedRoute 13Steps 3 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-106 | - | (S)-4-Chloro-3-hydroxybutanoic acid ethyl ester |
| Atorvastatin-107 | 112100-39-7 | Ethyl (3S)-3-hydroxy-4-iodobutanoate |
| Atorvastatin-108 | 130158-22-4 | Ethyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-iodobutanoate |
| Atorvastatin-109 | 430434-51-8 | Ethyl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]hex-5-enoate |
| Atorvastatin-094 | - | Chlorido(ethenyl)magnesium<-fgf->Chloro(vinyl)magnesium<-fgf->Vinylmagnesium chloride |
OptimisedRoute 14Steps 11 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-110 | 1375257-29-6 | (4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one |
| Atorvastatin-111 | - | Acetic acid chloride |
| Atorvastatin-112 | 1375257-24-1 | (4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one |
| Atorvastatin-113 | 19790-60-4 | 3-Benzyloxy-1-propanal |
| Atorvastatin-114 | - | (3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid |
| Atorvastatin-115 | 1824037-91-3 | (4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one |
| Atorvastatin-116 | - | (3R)-5-(Benzyloxy)-3-hydroxypentanoic acid |
| Atorvastatin-117 | 104713-29-3 | Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate |
| Atorvastatin-118 | 1256553-72-6 | Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate |
| Atorvastatin-119 | 1824037-92-4 | (4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one |
| Atorvastatin-120 | 1824037-97-9 | (3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid |
| Atorvastatin-121 | 1824037-93-5 | Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-122 | 119146-87-1 | Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate |
| Atorvastatin-123 | 1824037-94-6 | Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
OptimisedRoute 15Steps 3 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-124 | - | Methyl (3R,5R)-7-amino-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-125 | 1824037-95-7 | Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate |
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-123 | 1824037-94-6 | Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
OptimisedRoute 16Steps 11 · Total yield 25g(Atorvastatin-017)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-126 | 110-00-9Available | 1,4-Epoxy-1,3-butadiene |
| Atorvastatin-127 | - | (2E)-1,1,4,4-Tetramethoxybut-2-ene |
| Atorvastatin-128 | 57673-84-8 | 2,2-Dimethoxyacetaldehyde |
| Atorvastatin-129 | 75-52-5 | Nitrocarbol |
| Atorvastatin-130 | - | tert-Butyl 4-bromo-3-oxobutanoate |
| Atorvastatin-131 | 162972-45-4 | 1,1-Dimethoxy-3-nitropropan-2-ol |
| Atorvastatin-132 | 300720-95-0 | (1E)-3,3-Dimethoxy-1-nitroprop-1-ene |
| Atorvastatin-133 | 675201-91-9 | (2E)-3-Nitroprop-2-enal |
| Atorvastatin-134 | - | Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc |
| Atorvastatin-135 | 1841131-83-6 | tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate |
| Atorvastatin-136 | 674-82-8Available | 4-Methylene-2-oxetanone |
| Atorvastatin-137 | 1841131-84-7 | tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate |
| Atorvastatin-138 | 67-64-1 | 2-Propanone |
| Atorvastatin-139 | 1841131-85-8 | tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
OptimisedRoute 17Steps 15 · Total yield 36.3gAtorvastatin-152)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-140 | 1783-96-6 | (2R)-2-Aminobutanedioic acid |
| Atorvastatin-141 | 4198-33-8 | (2R)-2-Chlorobutanedioic acid |
| Atorvastatin-142 | 101021-57-2 | (2R)-2-Chlorobutane-1,4-diol |
| Atorvastatin-143 | - | 2-[(2S)-Oxiran-2-yl]ethan-1-ol |
| Atorvastatin-144 | 2089224-18-8 | (4S,6S)-4-[2-(Benzyloxy)ethyl]-6-(bromomethyl)-1,3-dioxan-2-one |
| Atorvastatin-145 | - | (2S)-2-[2-(Benzyloxy)ethyl]oxirane |
| Atorvastatin-146 | 91285-62-0 | (3R)-1-(Benzyloxy)hex-5-en-3-ol |
| Atorvastatin-147 | 204448-48-6 | (3R)-1-(Benzyloxy)hex-5-en-3-yl tert-butyl carbonate |
| Atorvastatin-148 | 2089224-19-9 | (4S,6S)-4-[2-(Benzyloxy)ethyl]-6-(bromomethyl)-2,2-dimethyl-1,3-dioxane |
| Atorvastatin-149 | 2089224-20-2 | 6-O-Acetyl-1-O-benzyl-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexitol |
| Atorvastatin-150 | 114861-21-1 | 1-O-Benzyl-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexitol |
| Atorvastatin-151 | 106799-15-9 | 6-O-Benzyl-3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexose |
| Atorvastatin-152 | 1262052-10-7 | 2-[(4R,6S)-6-[2-(Benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]ethanamine |
| Atorvastatin-153 | 2089224-21-3 | (6xi)-1-O-Benzyl-2,4,7-trideoxy-3,5-O-(1-methylethylidene)-7-nitro-D-erythro-heptitol |
| Atorvastatin-154 | 2089224-22-4 | (6xi)-6-O-Acetyl-1-O-benzyl-2,4,7-trideoxy-3,5-O-(1-methylethylidene)-7-nitro-D-erythro-heptitol |
| Atorvastatin-155 | 2089224-23-5 | (4S,6R)-4-[2-(Benzyloxy)ethyl]-2,2-dimethyl-6-(2-nitroethyl)-1,3-dioxane |
| Atorvastatin-138 | 67-64-1 | 2-Propanone |
| Atorvastatin-129 | 75-52-5 | Nitrocarbol |
| Atorvastatin-094 | 3536-96-7 | Chlorido(ethenyl)magnesium |
OptimisedRoute 18Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-156 | 1116-98-9 | 1,1-Dimethylethyl cyanoacetate |
| Atorvastatin-157 | 106-95-6Available | 1-Bromo-2-propene |
| Atorvastatin-158 | 2770108-45-5 | tert-Butyl 3-oxohex-5-enoate |
| Atorvastatin-159 | 554432-27-8 | tert-Butyl (3R)-3-hydroxyhex-5-enoate |
| Atorvastatin-160 | 1660128-90-4 | tert-Butyl [(4R,6S)-6-(bromomethyl)-2-oxo-1,3-dioxan-4-yl]acetate |
| Atorvastatin-161 | - | [(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate |
| Atorvastatin-162 | - | (4R,6S)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-dimethylethyl ester |
OptimisedRoute 19Steps 6 · Total yield 206.7g(Atorvastatin-161)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-163 | 86728-85-0 | Methyl (3S)-4-chloro-3-hydroxybutanoate |
| Atorvastatin-164 | - | Methyl (3S)-4-chloro-3-[(trimethylsilyl)oxy]butanoate |
| Atorvastatin-165 | - | (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanal |
| Atorvastatin-166 | 154026-93-4 | tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate |
| Atorvastatin-167 | 154026-94-5 | tert-Butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-161 | - | [(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-083 | 77-76-9Available | 1-Methoxy-1-methylethyl methyl ether |
OptimisedRoute 20Steps 1 · Total yield 57g(Atorvastatin-169)
| Code | CAS No. | Intermediate |
|---|---|---|
| Atorvastatin-168 | 84367-31-7 | (R)-(+)-4-Chloro-3-hydroxybutyronitrile |
| Atorvastatin-169 | - | tert-Butyl [(3R)-4-chloro-3-hydroxybutyl]carbamate |
Frequently asked questions
What are the approved indications of Atorvastatin strontium?
Approved indications include: 高脂血症.
When does the Atorvastatin strontium patent expire?
No public expiry year is available for Atorvastatin strontium yet; this page updates once verified.
How many synthesis routes are recorded for Atorvastatin strontium?
20 synthesis routes are recorded; the shortest is 1 steps with 50.7g(Atorvastatin Strontium) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Atorvastatin strontium intermediates?
5 intermediate CAS of Atorvastatin strontium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Atorvastatin strontium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24