CAS 14394-70-8

2-chloro-5-methylpyrimidin-4-amine

Codes：FEDR-002

Application context (from source-drug indications)

骨髓纤维化Fedratinib脾大Fedratinib原发性血小板增多症Fedratinib真性红细胞增多症Fedratinib骨髓增生性疾病Fedratinib骨髓增生异常综合征Fedratinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
FedratinibFedratinib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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Fedratinib原研路线steps: 2total yield: 40 mg

3-bromo-N-(tert-butyl)benzenesulfonamide→2-chloro-5-methylpyrimidin-4-amine→N-(tert-butyl)-3-((2-chloro-5-methylpyrimidin-4-yl)amino)benzenesulfonamide→4-(2-(pyrrolidin-1-yl)ethoxy)aniline

Intermediates available on this site

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