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CAS 1448588-52-0
N,N'-((((2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(oxy))bis(5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-6,4-diyl))bis(4-(tert-butyl)benzenesulfonamide)
Codes: BOSE-024
Application context (from source-drug indications)
溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Bosentan Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→4-(tert-butyl)-N-(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide→4-(tert-butyl)-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide→(2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol→N,N'-((((2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(oxy))bis(5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-6,4-diyl))bis(4-(tert-butyl)benzenesulfonamide)→N,N'-(((2,3-dihydroxybutane-1,4-diyl)bis(oxy))bis(5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-6,4-diyl))bis(4-(tert-butyl)benzenesulfonamide)
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