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CAS 6292-59-7

4-(tert-butyl)benzenesulfonamide

Codes: BOSE-007

Application context (from source-drug indications)

溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate

Source drugs (routes using this intermediate)

DrugTierExpiry
Bosentan HydrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Bosentan HydrateOptimised routesteps: 3total yield: 107 mg
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→2-((tetrahydro-2H-pyran-2-yl)oxy)ethan-1-ol→4-chloro-5-(2-methoxyphenoxy)-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-2,2'-bipyrimidine→4-(tert-butyl)-N-(5-(2-methoxyphenoxy)-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Bosentan HydrateProcess routesteps: 5total yield: 214.47 g
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione→potassium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide→2-(tert-butoxy)ethanol→N-(6-(2-(tert-butoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(tert-butyl)benzenesulfonamide→2-((6-((4-(tert-butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl formate

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