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CAS 1454847-98-3
(R)-3-(1-(5-fluoro-2-iodophenyl)ethoxy)pyridin-2-amine
Codes：LORL-005
Application context (from source-drug indications)
非小细胞肺癌洛拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 洛拉替尼Lorlatinib | Tier B — Position early | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(5-fluoro-2-iodophenyl)ethanone→(S)-1-(5-fluoro-2-iodophenyl)ethanol→(S)-1-(5-fluoro-2-iodophenyl)ethyl methanesulfonate→2-aminopyridin-3-ol→(R)-3-(1-(5-fluoro-2-iodophenyl)ethoxy)pyridin-2-amine→(R)-methyl 2-(1-((2-aminopyridin-3-yl)oxy)ethyl)-4-fluorobenzoate→(R)-methyl 2-(1-((2-amino-5-bromopyridin-3-yl)oxy)ethyl)-4-fluorobenzoate→tert-butyl ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→(R)-methyl 2-(1-((2-amino-5-(3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-5-cyano-1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoate→(R)-2-(1-((2-amino-5-(3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-5-cyano-1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic acid→(R)-2-(1-((2-amino-5-(5-cyano-1-methyl-3-((methylamino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic acid hydrochloride
(R)-3-(1-(5-fluoro-2-iodophenyl)ethoxy)pyridin-2-amine→tert-butyl ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→ethyl 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate→ethyl 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole-5-carboxylate→tert-butyl methylcarbamate→ethyl 4-bromo-3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylate→4-bromo-3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylic acid→tert-butyl ((4-bromo-5-carbamoyl-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→tert-butyl ((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile→(R)-2-(1-((2-aminopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide→(R)-2-(1-((2-amino-5-bromopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide→(R)-2-(1-((2-(N-acetylacetamido)-5-bromopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide
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