← Back to patent-cliff list
CAS 1454848-22-6
4-bromo-3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylic acid
Codes：LORL-016
Application context (from source-drug indications)
非小细胞肺癌洛拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 洛拉替尼Lorlatinib | Tier B — Position early | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-3-(1-(5-fluoro-2-iodophenyl)ethoxy)pyridin-2-amine→tert-butyl ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→ethyl 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate→ethyl 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole-5-carboxylate→tert-butyl methylcarbamate→ethyl 4-bromo-3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylate→4-bromo-3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylic acid→tert-butyl ((4-bromo-5-carbamoyl-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→tert-butyl ((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate→1-methyl-3-((methylamino)methyl)-1H-pyrazole-5-carbonitrile→(R)-2-(1-((2-aminopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide→(R)-2-(1-((2-amino-5-bromopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide→(R)-2-(1-((2-(N-acetylacetamido)-5-bromopyridin-3-yl)oxy)ethyl)-N-((5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)-4-fluoro-N-methylbenzamide
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.