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CAS 146-92-9
6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine 1-oxide
Codes：CANG-002
Application context (from source-drug indications)
冠状动脉血栓坎格雷洛四钠盐心肌梗塞坎格雷洛四钠盐血栓形成坎格雷洛四钠盐急性冠脉综合征坎格雷洛四钠盐冠状动脉病变坎格雷洛四钠盐动脉粥样硬化坎格雷洛四钠盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 坎格雷洛四钠盐Cangrelor Tetrasodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2R,3R,4R,5R)-2-(6-acetamido-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl diacetate→(2-chloroethyl)(methyl)sulfane→(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(N-(2-(methylthio)ethyl)acetamido)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate→(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol→((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate→tributylamine (dichloromethylene)bis(phosphonate)→CANG-013→(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine 1-oxide→(Z)-5-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-N'-hydroxy-1H-imidazole-4-carboximidamide→(2R,3R,4S,5R)-2-(6-amino-2-mercapto-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrate→3-chloro-1,1,1-trifluoropropane→(2R,3R,4S,5R)-2-(6-amino-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | (2R,3S,4R,5R)-2-(hydroxyMethyl)-5-(6-((2-(Methylthio)ethyl)aMino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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