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CAS 1464999-05-0

4-(5-(bis(2-hydroxyethyl)amino)-2-hydroxy-1-methyl-2,3-dihydro-1H-benzo[d]imidazol-2-yl)butanoic acid

CodesBENDAM-021

Application context (from source-drug indications)

B-细胞淋巴瘤盐酸苯达莫司汀非霍奇金淋巴瘤盐酸苯达莫司汀慢性淋巴细胞白血病盐酸苯达莫司汀套细胞淋巴瘤盐酸苯达莫司汀淋巴瘤盐酸苯达莫司汀多发性骨髓瘤盐酸苯达莫司汀

Source drugs (routes using this intermediate)

DrugTierExpiry
盐酸苯达莫司汀Bendamustine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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盐酸苯达莫司汀优化路线steps: 5total yield: 3.3 g
dihydro-2H-pyran-2,6(3H)-dione2,2'-((4-fluoro-3-nitrophenyl)azanediyl)bis(ethan-1-ol)2,2'-((4-(methylamino)-3-nitrophenyl)azanediyl)bis(ethan-1-ol)2,2'-((3-amino-4-(methylamino)phenyl)azanediyl)bis(ethan-1-ol)4-(5-(bis(2-hydroxyethyl)amino)-2-hydroxy-1-methyl-2,3-dihydro-1H-benzo[d]imidazol-2-yl)butanoic acidmethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

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