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CAS 1474024-66-2
(R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanone
Codes: VORI-021
Application context (from source-drug indications)
Fungal infectionVoriconazoleCandidaemiaVoriconazoleCandidiasisVoriconazoleAspergillus infectionVoriconazole新型隐球菌感染Voriconazole镰刀菌感染Voriconazole
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Voriconazole | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-chloro-1-(2,4-difluorophenyl)ethan-1-one→(((2S,3S,4R)-4-(4,5-difluoro-2-hydroxyphenoxy)-3-hydroxytetrahydro-2H-pyran-2-yl)methyl)diphenylphosphine oxide→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal→4-bromo-5-fluoropyrimidine→(R)-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanol→(R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanone→methyltriphenylphosphonium bromide→(R)-4-(1-(2-(2,4-difluorophenyl)oxiran-2-yl)vinyl)-5-fluoropyrimidine→4-((S)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine→1H-1,2,4-triazole
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