Voriconazole
Tier C — Watch / tradeVoriconazole
Targets：CYP51A1
Brand：Vfend
Indications (approved)：Fungal infection, Candidaemia, Candidiasis, Aspergillus infection, 新型隐球菌感染, 镰刀菌感染
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| VORI-001 | 759-67-1 | ethyl 2-fluoro-3-oxopentanoate |
| VORI-002 | 3473-63-0 | acetic acid;methanimidamide |
| VORI-003 | 137234-87-8 | 6-ethyl-5-fluoropyrimidin-4(3H)-one |
| VORI-004 | 137234-74-3 | 4-chloro-6-ethyl-5-fluoropyrimidine |
| VORI-005 | 86404-63-9 | 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one |
| VORI-006 | 188416-35-5 | 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
| VORI-007 | 182230-43-9 | 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
| Code | CAS No. | Intermediate |
|---|---|---|
| VORI-004 | 137234-74-3 | 4-chloro-6-ethyl-5-fluoropyrimidine |
| VORI-005 | 86404-63-9 | 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one |
| VORI-007 | 182230-43-9 | 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
| VORI-008 | 675-21-8 | 5-fluoropyrimidine |
| VORI-009 | 2927-71-1Available | 2,4-dichloro-5-fluoropyrimidine |
| VORI-010 | 137234-85-6 | 2,4-dichloro-6-ethyl-5-fluoropyrimidine |
| VORI-011 | - | 4-((l5-azanyl)oxy)-2-chloro-6-ethyl-5-fluoropyrimidine |
| VORI-012 | - | 6-ethyl-5-fluoropyrimidin-4-ol |
| VORI-013 | 188416-28-6 | 4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine |
| VORI-014 | 188416-20-8 | 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| VORI-015 | 51336-94-8 | 2-chloro-1-(2,4-difluorophenyl)ethan-1-one |
| VORI-016 | 454475-43-5 | (((2S,3S,4R)-4-(4,5-difluoro-2-hydroxyphenoxy)-3-hydroxytetrahydro-2H-pyran-2-yl)methyl)diphenylphosphine oxide |
| VORI-017 | 861718-83-4 | (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile |
| VORI-018 | 861718-85-6 | (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal |
| VORI-019 | 1003706-87-3 | 4-bromo-5-fluoropyrimidine |
| VORI-020 | 1474024-65-1 | (R)-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanol |
| VORI-021 | 1474024-66-2 | (R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanone |
| VORI-022 | 1779-49-3 | methyltriphenylphosphonium bromide |
| VORI-023 | 1474024-67-3 | (R)-4-(1-(2-(2,4-difluorophenyl)oxiran-2-yl)vinyl)-5-fluoropyrimidine |
| VORI-024 | 1474024-68-4 | 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine |
| VORI-025 | 288-88-0Available | 1H-1,2,4-triazole |
Frequently asked questions
What are the approved indications of Voriconazole?
Approved indications include: Fungal infection, Candidaemia, Candidiasis, Aspergillus infection, 新型隐球菌感染, 镰刀菌感染.
When does the Voriconazole patent expire?
No public expiry year is available for Voriconazole yet; this page updates once verified.
How many synthesis routes are recorded for Voriconazole?
3 synthesis routes are recorded; the shortest is 5 steps with 0.63 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Voriconazole intermediates?
2 intermediate CAS of Voriconazole are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Voriconazole intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27