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CAS 1486480-83-4
(1R,2R,4R,5S)-1-(3,5-bis(trifluoromethyl)benzyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide
Codes：EFAV-018
Application context (from source-drug indications)
HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethynylcyclopropane→2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→5-chloro-2-nitrobenzaldehyde→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one→(1R,2R,4R,5S)-1-(3,5-bis(trifluoromethyl)benzyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide→(S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→4-nitrophenyl carbonochloridate
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