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CAS 168834-43-3
2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
Codes：EFAV-006
Application context (from source-drug indications)
HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-chloroaniline→pivaloyl chloride→N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one→(1S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride→(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1-((4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
ethynylcyclopropane→2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→5-chloro-2-nitrobenzaldehyde→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol→1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one→(1R,2R,4R,5S)-1-(3,5-bis(trifluoromethyl)benzyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide→(S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→4-nitrophenyl carbonochloridate
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