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CAS 1594-58-7

N'-hydroxypyridine-3-carboximidamide

Codes: (X)320339-3-b

Application context (from source-drug indications)

C型尼曼匹克病Arimoclomol Citrate包涵体肌炎Arimoclomol CitrateIII 型戈谢病Arimoclomol CitrateI 型戈谢病Arimoclomol CitrateAmyotrophic lateral sclerosisArimoclomol Citrate

Source drugs (routes using this intermediate)

DrugTierExpiry
Arimoclomol CitrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Arimoclomol CitrateOptimised routesteps: 4total yield: /
(R)-(-)-Glycidyl m-nitrobenzenesulfonate→Azacyclohexane→N-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidoyl chloride→N'-hydroxypyridine-3-carboximidamide→N'-[[(2R)-Oxiran-2-yl]methoxy]pyridine-3-carboximidamide→N'-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]pyridine-3-carboximidamide→N-[(2R)-2-hydroxy-3-(piperidin-1-yl)propoxy]pyridine-3-carbonimidoyl chloride

Intermediates available on this site

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