CAS 1610595-14-6

1-(benzyloxy)-2,4-di-tert-butyl-5-nitrobenzene

Codes：IVAC-030

Application context (from source-drug indications)

囊性纤维化艾伐卡托慢性支气管炎艾伐卡托慢性阻塞性肺疾病艾伐卡托鼻窦炎艾伐卡托

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
艾伐卡托Ivacaftor	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

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艾伐卡托优化路线steps: 5total yield: 15.8 g

ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate→2,4-di-tert-butylphenol→2,4-di-tert-butyl-5-nitrophenol→1-(benzyloxy)-2,4-di-tert-butyl-5-nitrobenzene→5-(benzyloxy)-2,4-di-tert-butylaniline→N-(5-(benzyloxy)-2,4-di-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

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