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CAS 1638678-46-2
((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate
Codes: OXYC-018
Application context (from source-drug indications)
PainNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateRestless legs syndromeNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateCancer painNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateChronic painNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateOsteoarthritisNaloxone Hydrochloride/Oxycodone Hydrochloride HydrateLow back painNaloxone Hydrochloride/Oxycodone Hydrochloride HydratePainOxycodone Hydrochloride Hydrate急性疼痛Oxycodone Hydrochloride HydrateChronic painOxycodone Hydrochloride HydratePostoperative painOxycodone Hydrochloride Hydrate呼吸障碍Oxycodone Hydrochloride HydrateAnxiety disorderOxycodone Hydrochloride Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate | Tier C — Watch / trade | - |
| Oxycodone Hydrochloride Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Naloxone Hydrochloride/Oxycodone Hydrochloride HydrateOptimised routesteps: 22total yield: 3.4 mg (Oxycodone)
2-bromo-3-hydroxy-4-methoxybenzaldehyde→2-bromo-4-methoxy-3-(methoxymethoxy)benzaldehyde→(2-bromo-4-methoxy-3-(methoxymethoxy)phenyl)methanol→2-bromo-1-(bromomethyl)-4-methoxy-3-(methoxymethoxy)benzene→(R)-4-benzyl-3-(2-(4-(benzyloxy)phenyl)acetyl)oxazolidin-2-one→(R)-4-benzyl-3-((R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one→(R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoic acid→methyl (R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoate→methyl (R)-6-(benzyloxy)-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthrene-9-carboxylate→(R)-(6-hydroxy-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,8a,9,10-tetrahydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,7,8,8a,9,10-hexahydrophenanthren-9-yl)methyl acetate→methyl 3-chloro-3-oxopropanoate→(8aR,9S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6-oxo-7,8,9,10-tetrahydrophenanthren-8a(6H)-yl methyl malonate→methyl (4bS,8aR,9S,13S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthrene-13-carboxylate→((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bR,8aR,9S)-5-bromo-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 8-[(acetyloxy)methyl]-6,7,8,9-tetrahydro-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 6,7,8,9-tetrahydro-8-(hydroxymethyl)-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxylic acid, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxamide, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-4,4a,5,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-2,7(3H,7aH)-dione→(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
2-bromo-3-hydroxy-4-methoxybenzaldehyde→2-bromo-4-methoxy-3-(methoxymethoxy)benzaldehyde→(2-bromo-4-methoxy-3-(methoxymethoxy)phenyl)methanol→2-bromo-1-(bromomethyl)-4-methoxy-3-(methoxymethoxy)benzene→(R)-4-benzyl-3-(2-(4-(benzyloxy)phenyl)acetyl)oxazolidin-2-one→(R)-4-benzyl-3-((R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one→(R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoic acid→methyl (R)-2-(4-(benzyloxy)-2-bromophenyl)-3-(4-methoxy-3-(methoxymethoxy)phenyl)propanoate→methyl (R)-6-(benzyloxy)-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthrene-9-carboxylate→(R)-(6-hydroxy-3-methoxy-4-(methoxymethoxy)-9,10-dihydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,8a,9,10-tetrahydrophenanthren-9-yl)methyl acetate→((8aR,9S)-8a-hydroxy-3-methoxy-4-(methoxymethoxy)-6-oxo-6,7,8,8a,9,10-hexahydrophenanthren-9-yl)methyl acetate→methyl 3-chloro-3-oxopropanoate→(8aR,9S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6-oxo-7,8,9,10-tetrahydrophenanthren-8a(6H)-yl methyl malonate→methyl (4bS,8aR,9S,13S)-9-(acetoxymethyl)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthrene-13-carboxylate→((4bS,8aR,9S)-3-methoxy-4-(methoxymethoxy)-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bS,8aR,9S)-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→((4bR,8aR,9S)-5-bromo-4-hydroxy-3-methoxy-6,12-dioxo-5,6,7,8,9,10-hexahydro-8a,4b-(epoxyethano)phenanthren-9-yl)methyl acetate→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 8-[(acetyloxy)methyl]-6,7,8,9-tetrahydro-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-5,11(4aH)-dione, 6,7,8,9-tetrahydro-8-(hydroxymethyl)-3-methoxy-, (4aR,7aR,8S,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxylic acid, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→7a,9c-(Epoxyethano)phenanthro[4,5-bcd]furan-8-carboxamide, 4a,5,6,7,8,9-hexahydro-3-methoxy-5,11-dioxo-, (4aR,7aR,8R,9cS)-→(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-4,4a,5,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-2,7(3H,7aH)-dione→(4R,4aS,7aR,12bS)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7-diol
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