CAS 1667739-36-7

(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl methanesulfonate

Codes：VENE-032

Application context (from source-drug indications)

急性髓细胞样白血病维奈克拉慢性淋巴细胞白血病维奈克拉

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
维奈克拉Venetoclax	Tier B — Position early	2030

Position in synthesis routes (up/downstream chain)

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维奈克拉优化路线steps: 6total yield: 98.00 mg

methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate→5-bromo-1H-pyrrolo[2,3-b]pyridine→5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→1H-pyrrolo[2,3-b]pyridin-5-ol→methyl 2-fluoro-4-nitrobenzoate→methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-nitrobenzoate→methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-aminobenzoate→bis(2-chloroethyl)amine→methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1-yl)benzoate→(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl methanesulfonate

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Pharmaceutical Intermediates	询价	询价	询价	—

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