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维奈克拉

Tier B — Position early

Venetoclax · all drugs expiring in 2030 →

艾伯维
Originator
2016
First approval
2030
Expiry (public)
$2.79B ▲
Peak sales
化学药
Type

Targets：BCL2

Brand：Venclyxto、Venclexta、唯可来

Indications (approved)：急性髓细胞样白血病、慢性淋巴细胞白血病

Regional status

US
批准上市
2016-04-11
EU
批准上市
2016-12-04
China
批准上市
2020-12-02
Japan
临床三期
2018-11-12

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 11 · Total yield 1.62 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
VENE-001183208-35-7Available5-bromo-1H-pyrrolo[2,3-b]pyridine
VENE-002858116-66-2Available5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
VENE-003685514-01-6Available1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
VENE-004106614-28-2Availablemethyl 2,4-difluorobenzoate
VENE-0051235865-75-4Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate
VENE-0061228780-72-0Available1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine
VENE-0071235865-76-5Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate
VENE-0081235865-77-6Available5-bromo-1H-pyrrolo[2,3-b]pyridine
VENE-0091228779-96-1Available5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
VENE-01032767-46-7Availablemethyl 4,4-dimethyl-2-oxocyclohexane-1-carboxylate
VENE-0111228780-46-8Availablemethyl 4,4-dimethyl-2-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene-1-carboxylate
VENE-0121679-18-1Available(4-chlorophenyl)boronic acid
VENE-0131228780-49-1Availablemethyl 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate
VENE-0141228780-51-5Available(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol
VENE-01557260-71-6Availabletert-butyl piperazine-1-carboxylate
VENE-0161228780-71-9Availabletert-butyl 4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine-1-carboxylate
OptimisedRoute 2Steps 9 · Total yield 32.00 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
VENE-0081235865-77-6Available5-bromo-1H-pyrrolo[2,3-b]pyridine
VENE-0091228779-96-1Available5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
VENE-0121679-18-1Available(4-chlorophenyl)boronic acid
VENE-01557260-71-6Availabletert-butyl piperazine-1-carboxylate
VENE-0161228780-71-9Availabletert-butyl 4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine-1-carboxylate
VENE-017105931-73-5Available4-bromo-2-fluoro-1-iodobenzene
VENE-018889858-12-2Available-
VENE-01998549-88-3Available1H-pyrrolo[2,3-b]pyridin-5-ol
VENE-0201628047-84-6Availabletert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate
VENE-0211228780-72-0Available1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine
VENE-022932710-63-9Available4-(di-tert-butylphosphanyl)-N,N-dimethylaniline
VENE-0231628047-90-4Availabletert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate
VENE-0242979-19-3Available3,3-dimethylcyclohexanone
VENE-0251228943-80-3Available2-chloro-4,4-dimethylcyclohex-1-ene-1-carbaldehyde
VENE-0261228837-05-5Available4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde
OptimisedRoute 3Steps 6 · Total yield 98.00 mg
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
VENE-0071235865-76-5Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate
VENE-0081235865-77-6Available5-bromo-1H-pyrrolo[2,3-b]pyridine
VENE-0091228779-96-1Available5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
VENE-01998549-88-3Available1H-pyrrolo[2,3-b]pyridin-5-ol
VENE-027392-09-6Availablemethyl 2-fluoro-4-nitrobenzoate
VENE-0281667739-34-5Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-nitrobenzoate
VENE-0291667739-35-6Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-aminobenzoate
VENE-030334-22-5Availablebis(2-chloroethyl)amine
VENE-0311257044-57-7Availablemethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1-yl)benzoate
VENE-0321667739-36-7Available(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl methanesulfonate

Frequently asked questions

What are the approved indications of Venetoclax?

Approved indications include: 急性髓细胞样白血病, 慢性淋巴细胞白血病.

When does the Venetoclax patent expire?

Based on public sources, the Venetoclax patent expires in 2030.

How many synthesis routes are recorded for Venetoclax?

3 synthesis routes are recorded; the shortest is 6 steps with 98.00 mg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Venetoclax intermediates?

31 intermediate CAS of Venetoclax are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Venetoclax intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24