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CAS 167095-12-7

(1E)-3-Ethoxy-3-oxo-1-phenyl-1-[(phenylcarbonyl)amino]prop-1-en-2-yl ethyl ethanedioate

Codes:(V)101438-50-a

Application context (from source-drug indications)

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate

Source drugs (routes using this intermediate)

DrugTierExpiry
Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Paclitaxel/Encequidar mesylate优化路线steps: 5total yield: /
(±)-alpha-Aminophenylacetic acid→alpha-Chlorobenzaldehyde→2-Phenyl-2-(phenylformamido)acetic acid→1-(Chlorocarbonyl)formic acid ethyl ester→(1E)-3-Ethoxy-3-oxo-1-phenyl-1-[(phenylcarbonyl)amino]prop-1-en-2-yl ethyl ethanedioate→Ethyl 2-oxo-3-phenyl-3-[(phenylcarbonyl)amino]propanoate→(±)-Ethyl (2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid

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