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CAS 171777-72-3
N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid
Codes：Folic Acid-036
Application context (from source-drug indications)
原发性高血压马来酸依那普利/叶酸巨幼红细胞性贫血叶酸叶酸缺乏叶酸神经管缺损叶酸贫血叶酸热潮红叶酸高同型半胱氨酸血症叶酸
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Enalapril Maleate/Folic AcidEnalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Folic AcidFolic Acid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene→2,3,5,6-Tetradeutero-4-nitrobenzoic acid→2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride→Diethyl L-glutamate hydrochloride→Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate→Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid
1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene→2,3,5,6-Tetradeutero-4-nitrobenzoic acid→2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride→Diethyl L-glutamate hydrochloride→Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate→Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate→N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide→2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate→N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid
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