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Folic Acid
Tier C — Watch / tradeFolic Acid
-
Originator
1947
First approval
-
Expiry (public)
$0.01B ▲
Peak sales
Small molecule
Type
Targets：Not applicable
Brand：Neocepri, Folvite
Indications (approved)：Megaloblastic anaemia, Folate deficiency, Neural tube defect
Regional status
US
Approved
1947-06-05
EU
No progress
2009-07-01
China
Approved
1981-01-01
Japan
Approved
1950-01-01
Factories producing this API5
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
5 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates16 routes
Originator routes × 0Optimised (non-patent) × 14Process routes × 2
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield /
Folic Acid-001684258-65-9Folic Acid-002876508-38-2Folic Acid-003—Folic Acid-004873397-19-4Folic Acid-00589794-15-0Folic Acid-00613726-52-8Folic Acid-00752534-76-6API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-001 | 684258-65-9 | 1-(2-Amino-4-oxo-3,4-dihydropteridin-6-ylmethyl)pyridinium iodide |
| Folic Acid-002 | 876508-38-2 | 2-Amino-6-methyl-3,4,5,8-tetrahydropteridin-4-one |
| Folic Acid-003 | - | 2-Amino-6-methylpteridin-4(3H)-one |
| Folic Acid-004 | 873397-19-4 | 2-Amino-6-(chloromethyl)pteridin-4(3H)-one |
| Folic Acid-005 | 89794-15-0 | 2-Amino-6-(bromomethyl)pteridin-4(3H)-one |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-007 | 52534-76-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester |
OptimisedRoute 2Steps 2 · Total yield /
Folic Acid-00829769-49-1Folic Acid-009—Folic Acid-010—API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-009 | - | 4(S)-(4-Aminobenzamido)-5-ethoxy-5-oxopentanoic acid |
| Folic Acid-010 | - | 4(S)-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethyleneamino)benzamido]-5-ethoxy-5-oxopentanoic acid |
OptimisedRoute 3Steps 3 · Total yield /
Folic Acid-0115221-17-0Folic Acid-012110-86-1Folic Acid-013878776-10-4Folic Acid-0141004-75-7Folic Acid-001684258-65-9Folic Acid-0154271-30-1API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-012 | 110-86-1 | Azabenzene |
| Folic Acid-013 | 878776-10-4 | 1-(2-Bromo-3-oxopropyl)pyridinium bromide |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-001 | 684258-65-9 | 1-(2-Amino-4-oxo-3,4-dihydropteridin-6-ylmethyl)pyridinium iodide |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
OptimisedRoute 4Steps 2 · Total yield /
Folic Acid-016636-38-4Folic Acid-00613726-52-8Folic Acid-017—Folic Acid-0141004-75-7API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-016 | 636-38-4 | 2,3-Dihydroxy-2-propenal |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-017 | - | N-[4-[2,3-Dihydroxy-2-propenylideneamino]benzoyl]-L-glutamic acid diethyl diester |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
OptimisedRoute 5Steps 4 · Total yield /
Folic Acid-018712-30-1Folic Acid-019—Folic Acid-02052407-60-0Folic Acid-02159091-92-8Folic Acid-02252407-61-1API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-018 | 712-30-1 | 2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde |
| Folic Acid-019 | - | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide dihydrate |
| Folic Acid-020 | 52407-60-0 | N-(4-Aminobenzoyl)-L-glutamic acid dimethyl diester |
| Folic Acid-021 | 59091-92-8 | N-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethyleneamino)benzoyl]-L-glutamic acid dimethyl diester |
| Folic Acid-022 | 52407-61-1 | N-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid dimethyl diester |
OptimisedRoute 6Steps 4 · Total yield /
Folic Acid-0154271-30-1Folic Acid-00613726-52-8Folic Acid-0115221-17-0Folic Acid-024—Folic Acid-0141004-75-7Folic Acid-00752534-76-6API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-024 | - | N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-007 | 52534-76-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester |
OptimisedRoute 7Steps 1 · Total yield /
Folic Acid-0141004-75-7Folic Acid-0154271-30-1Folic Acid-02510140-89-3Folic Acid-0115221-17-0API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-025 | 10140-89-3 | 2,3-Dichloropropanal |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
OptimisedRoute 8Steps 1 · Total yield /
Folic Acid-0262536-53-0Folic Acid-02753053-54-6API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-026 | 2536-53-0 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)-3,5-dibromobenzoyl]-L-glutamic acid |
| Folic Acid-027 | 53053-54-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)-3,5-dideuterobenzoyl]-L-glutamic acid |
OptimisedRoute 9Steps 8 · Total yield /
Folic Acid-028—Folic Acid-029171777-66-5Folic Acid-030171777-67-6Folic Acid-0311118-89-4Folic Acid-032171777-68-7Folic Acid-033171777-69-8Folic Acid-00829769-49-1Folic Acid-018712-30-1Folic Acid-034—Folic Acid-035171777-71-2Folic Acid-036171777-72-3API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-028 | - | 1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene |
| Folic Acid-029 | 171777-66-5 | 2,3,5,6-Tetradeutero-4-nitrobenzoic acid |
| Folic Acid-030 | 171777-67-6 | 2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride |
| Folic Acid-031 | 1118-89-4 | Diethyl L-glutamate hydrochloride |
| Folic Acid-032 | 171777-68-7 | Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate |
| Folic Acid-033 | 171777-69-8 | Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate |
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-018 | 712-30-1 | 2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde |
| Folic Acid-034 | - | Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate |
| Folic Acid-035 | 171777-71-2 | Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate |
| Folic Acid-036 | 171777-72-3 | N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid |
OptimisedRoute 10Steps 2 · Total yield /
Folic Acid-037—Folic Acid-038156045-54-4Folic Acid-039156045-55-5Folic Acid-0141004-75-7Folic Acid-0154271-30-1Folic Acid-040—API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-037 | - | [1,3-13C]Propan-2-one |
| Folic Acid-038 | 156045-54-4 | 1,1,3-Trichloro[1,3-13C]propan-2-one |
| Folic Acid-039 | 156045-55-5 | 1,3-Dichloro[1,3-13C]propan-2-one |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-040 | - | N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid |
OptimisedRoute 11Steps 12 · Total yield /
Folic Acid-041107-02-8Folic Acid-0115221-17-0Folic Acid-0426630-39-3Folic Acid-043125072-36-8Folic Acid-044100707-85-5Folic Acid-04528621-39-8Folic Acid-046—Folic Acid-0474227-30-9Folic Acid-04892104-52-4Folic Acid-00829769-49-1Folic Acid-0154271-30-1Folic Acid-049883451-68-1Folic Acid-050233600-79-8API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-041 | 107-02-8 | 2-Propenal |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-042 | 6630-39-3 | 2-Bromo-1,1,3-triethoxypropane |
| Folic Acid-043 | 125072-36-8 | 1,3,3-Triethoxyprop-1-ene |
| Folic Acid-044 | 100707-85-5 | 1,2-Dibromo-1,3,3-triethoxypropane |
| Folic Acid-045 | 28621-39-8 | 2-Bromo-3,3-diethoxypropanal |
| Folic Acid-046 | - | 2,5,6-Triaminopyrimidin-4(5H)-one hydrochloride |
| Folic Acid-047 | 4227-30-9 | 2-Amino-6-(diethoxymethyl)pteridin-4(1H)-one |
| Folic Acid-048 | 92104-52-4 | N-[6-(Diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide |
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-049 | 883451-68-1 | N-([4-[[[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl](formyl)amino]phenyl]carbonyl)-L-glutamic acid |
| Folic Acid-050 | 233600-79-8 | N-[[4-([[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)phenyl]carbonyl]-L-glutamic acid |
OptimisedRoute 12Steps 4 · Total yield 38.92g(Folic Acid (Free))
Folic Acid-051122-04-3Folic Acid-05256-86-0Folic Acid-0536758-40-3Folic Acid-054—Folic Acid-0154271-30-1Folic Acid-0141004-75-7Folic Acid-055—Folic Acid-056921-03-9API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-051 | 122-04-3 | 4-Nitrobenzoyl chloride |
| Folic Acid-052 | 56-86-0 | (S)-(+)-Glutamic acid |
| Folic Acid-053 | 6758-40-3 | (2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid |
| Folic Acid-054 | - | Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-055 | - | 2,5,6-Triaminopyrimidin-4-one sulfate |
| Folic Acid-056 | 921-03-9 | 1,1,3-Trichloroacetone |
OptimisedRoute 13Steps 7 · Total yield 18.76g(Folic Acid (Free))
Folic Acid-057105-34-0Folic Acid-058—Folic Acid-05956-06-4Folic Acid-0602387-48-6Folic Acid-061—Folic Acid-06235011-47-3Folic Acid-0632035099-30-8Folic Acid-06451324-37-9Folic Acid-065112740-59-7Folic Acid-06614337-41-8Folic Acid-067—Folic Acid-068—Folic Acid-0154271-30-1API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-057 | 105-34-0Available | (Methoxycarbonyl)acetonitrile |
| Folic Acid-058 | - | Guanidine sulfate |
| Folic Acid-059 | 56-06-4 | 2,4-Diamino-6-hydroxypyrimidine |
| Folic Acid-060 | 2387-48-6 | 2,4-Diamino-6-hydroxy-5-nitrosopyrimidine |
| Folic Acid-061 | - | 2,5,6-Triaminopyrimidin-4-ol |
| Folic Acid-062 | 35011-47-3 | Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one |
| Folic Acid-063 | 2035099-30-8 | 2,5,6-Triaminopyrimidin-4-ol dihydrobromide |
| Folic Acid-064 | 51324-37-9 | 2,5,6-Triaminopyrimidin-4-one dihydrochloride |
| Folic Acid-065 | 112740-59-7 | 3-Bromo-2-oxopropanal oxime |
| Folic Acid-066 | 14337-41-8 | 1-Chloro-3-(hydroxyimino)propan-2-one |
| Folic Acid-067 | - | 2-Amino-6-(bromomethyl)-4-pteridinol |
| Folic Acid-068 | - | 2-Amino-6-(chloromethyl)-4-pteridinol |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
OptimisedRoute 16Steps 7 · Total yield 1.5g(Folic Acid (Free))
Folic Acid-07594-09-7Folic Acid-076106-89-8Folic Acid-077—Folic Acid-078—Folic Acid-079—Folic Acid-080—Folic Acid-081—Folic Acid-082—Folic Acid-08316450-41-2Folic Acid-084—API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-075 | 94-09-7 | 4-(Ethoxycarbonyl)aniline |
| Folic Acid-076 | 106-89-8 | (+/-)-2-(Chloromethyl)oxirane |
| Folic Acid-077 | - | Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate |
| Folic Acid-078 | - | Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate |
| Folic Acid-079 | - | Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate |
| Folic Acid-080 | - | 2,4,5-Triamino-6-hydroxypyrimidine sulfate |
| Folic Acid-081 | - | Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate |
| Folic Acid-082 | - | 4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid |
| Folic Acid-083 | 16450-41-2 | (S)-Glutamic acid diethyl ester |
| Folic Acid-084 | - | Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate |
ProcessRoute 14Steps 1 · Total yield 1898.52g(Folic Acid (Free))
Folic Acid-0536758-40-3Folic Acid-0602387-48-6Folic Acid-069—API · Folic Acid
ProcessRoute 15Steps 5 · Total yield 20.58-21.35kg(Folic Acid (Free))
Folic Acid-070105-56-6Folic Acid-07150-01-1Folic Acid-0591956-06-04Folic Acid-0602387-48-6Folic Acid-0141004-75-7Folic Acid-041107-02-8Folic Acid-072619-45-4Folic Acid-07334794-87-1Folic Acid-074142-47-2,138-15-8API · Folic Acid
| Code | CAS No. | Intermediate |
|---|---|---|
| Folic Acid-070 | 105-56-6Available | 2-Cyanoacetic acid ethyl ester |
| Folic Acid-071 | 50-01-1 | Aminoformamidine hydrochloride |
| Folic Acid-059 | 1956-06-04 | 2,4-Diamino-6-hydroxypyrimidine |
| Folic Acid-060 | 2387-48-6 | 2,4-Diamino-6-hydroxy-5-nitrosopyrimidine |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-041 | 107-02-8 | 2-Propenal |
| Folic Acid-072 | 619-45-4 | Methyl 4-aminobenzoate |
| Folic Acid-073 | 34794-87-1 | Methyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoate |
| Folic Acid-074 | 142-47-2,138-15-8 | L-Glutamic acid monosodium salt |
Frequently asked questions
What are the approved indications of Folic Acid?
Approved indications include: Megaloblastic anaemia, Folate deficiency, Neural tube defect.
When does the Folic Acid patent expire?
No public expiry year is available for Folic Acid yet; this page updates once verified.
How many synthesis routes are recorded for Folic Acid?
16 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Folic Acid intermediates?
2 intermediate CAS of Folic Acid are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Folic Acid intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27