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CAS 171866-30-1
(2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate
Codes：CLEVU-004
Application context (from source-drug indications)
乙型肝炎克拉夫定新型冠状病毒感染克拉夫定
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 克拉夫定Clevudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S,4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol→(2S,3S,4S)-2-((benzoyloxy)methyl)-5-methoxytetrahydrofuran-3,4-diyl dibenzoate→(2R,3S,4S,5S)-2-acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate→(2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate→(2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate→(2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate
(2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate→(2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate→(2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate→5-methylpyrimidine-2,4(1H,3H)-dione
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