克拉夫定
Tier C — Watch / tradeClevudine
Targets：HBV pol
Brand：Revovir、Levovir
Indications (approved)：乙型肝炎
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| CLEVU-001 | 41546-20-7 | (3S,4R,5S)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol |
| CLEVU-002 | 171866-28-7 | (2S,3S,4S)-2-((benzoyloxy)methyl)-5-methoxytetrahydrofuran-3,4-diyl dibenzoate |
| CLEVU-003 | 3080-30-6 | (2R,3S,4S,5S)-2-acetoxy-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate |
| CLEVU-004 | 171866-30-1 | (2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-005 | 171720-99-3 | (2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-006 | 171721-00-9 | (2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-007 | 171866-29-8 | ((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-008 | 7288-28-0 | 5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine |
| CLEVU-009 | 171721-03-2 | ((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| CLEVU-007 | 171866-29-8 | ((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-009 | 171721-03-2 | ((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-010 | 87-72-9 | (3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetraol |
| CLEVU-011 | 123163-97-3 | (3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate |
| CLEVU-012 | 14227-90-8 | (2R,3R,4S,5S)-2-bromotetrahydro-2H-pyran-3,4,5-triyl triacetate |
| CLEVU-013 | 3945-18-4 | (3S,4R)-3,4-dihydro-2H-pyran-3,4-diyl diacetate |
| CLEVU-014 | 442514-54-7 | (3S,4S,5R)-5-fluoro-6-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate |
| CLEVU-015 | - | (3R,4S,5S)-3-fluorotetrahydro-2H-pyran-2,4,5-triol |
| CLEVU-016 | 442514-57-0 | (2S,3S,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3-ol |
| CLEVU-017 | 442514-58-1 | ((2S,3S,4R,5R)-3-(benzoyloxy)-4-fluoro-5-methoxytetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-018 | 7288-28-0 | 5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine |
| Code | CAS No. | Intermediate |
|---|---|---|
| CLEVU-004 | 171866-30-1 | (2S,3S,4R,5S)-5-((benzoyloxy)methyl)-3-hydroxytetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-005 | 171720-99-3 | (2S,3S,4S,5S)-3-(((1H-imidazol-1-yl)sulfonyl)oxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-006 | 171721-00-9 | (2S,3R,4S,5S)-5-((benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate |
| CLEVU-007 | 171866-29-8 | ((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-009 | 171721-03-2 | ((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate |
| CLEVU-019 | 65-71-4 | 5-methylpyrimidine-2,4(1H,3H)-dione |
Frequently asked questions
What are the approved indications of Clevudine?
Approved indications include: 乙型肝炎.
When does the Clevudine patent expire?
No public expiry year is available for Clevudine yet; this page updates once verified.
How many synthesis routes are recorded for Clevudine?
3 synthesis routes are recorded; the shortest is 5 steps with 4.9 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Clevudine intermediates?
All intermediates in Clevudine routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Clevudine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24