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CAS 175837-07-7
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
Codes：SILO-010
Application context (from source-drug indications)
前列腺增生赛洛多辛下尿路症状赛洛多辛尿路结石症赛洛多辛肾结石赛洛多辛避孕行为赛洛多辛尿路结石赛洛多辛
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 赛洛多辛Silodosin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(1-acetylindolin-5-yl)propan-1-one→1-(1-acetylindolin-5-yl)-2-bromopropan-1-one→1-(5-(2-bromopropyl)indolin-1-yl)ethan-1-one→1-(5-(2-bromopropyl)-7-nitroindolin-1-yl)ethan-1-one→1-(7-amino-5-(2-bromopropyl)indolin-1-yl)ethan-1-one→1-acetyl-5-(2-bromopropyl)indoline-7-carbonitrile→1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile→1-acetyl-5-(2-aminopropyl)indoline-7-carbonitrile→1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene→1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→(R)-1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→tert-butyl (R)-(1-(1-acetyl-7-cyanoindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-cyanoindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-carbamoylindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate→tert-butyl (R)-(1-(1-(3-((tert-butyldimethylsilyl)oxy)propyl)-7-carbamoylindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-carbamoyl-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→2-methoxyphenol→1,1,1-trifluoro-2-iodoethane→1-methoxy-2-(2,2,2-trifluoroethoxy)benzene→2-(2,2,2-trifluoroethoxy)phenol→1,2-dibromoethane
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