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CAS 180973-26-6
(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid
Codes：ROMI-008
Application context (from source-drug indications)
外周T细胞淋巴瘤罗米地辛淋巴瘤罗米地辛嗜铬细胞瘤罗米地辛皮肤T细胞淋巴瘤罗米地辛非霍奇金淋巴瘤罗米地辛黑色素瘤罗米地辛
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 罗米地辛Romidepsin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(but-3-yn-1-yloxy)(tert-butyl)diphenylsilane→7-((tert-butyldiphenylsilyl)oxy)-1,1-dimethoxyhept-4-yn-3-one→ROMI-015→(R,E)-7-((tert-butyldiphenylsilyl)oxy)-1,1-dimethoxyhept-4-en-3-ol→(R,E)-5-hydroxy-7,7-dimethoxyhept-3-en-1-yl 4-methylbenzenesulfonate→methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threonyl-L-valinate→methyl N-((allyloxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate→methyl ((Z)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→methyl ((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→methyl ((Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid→methyl ((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→(3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone→methyl 3,3-dimethoxypropanoate→N,3,3-trimethoxy-N-methylpropanamide
methyl ((Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid→methyl ((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate→(S)-methyl 2-amino-3-methylbutanoate→methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate→methyl N-((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate→methyl N-(N-((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)-S-trityl-D-cysteinyl)-O-tosyl-L-threonyl-L-valinate→((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine→(3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone→methyl (E)-penta-2,4-dienoate→(E)-5-(tritylthio)pent-2-enal→((1-(benzyloxy)vinyl)oxy)trimethylsilane→benzyl (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoate
(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid→ROMI-028→ROMI-029→ROMI-030→ROMI-031→ROMI-032→((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine→ROMI-034→ROMI-035→(S,E)-3-hydroxy-1-((R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-(tritylthio)hept-4-en-1-one
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