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罗米地辛
Tier C — Watch / tradeRomidepsin
新基公司
Originator
2009
First approval
-
Expiry (public)
$0.08B ▲
Peak sales
化学药
Type
Targets：HDAC
Brand：Istodax
Indications (approved)：外周T细胞淋巴瘤、淋巴瘤
Regional status
US
批准上市
2009-11-05
EU
终止
China
-
Japan
批准上市
2017-07-03
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 1 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| ROMI-001 | - | - |
| ROMI-002 | - | - |
OptimisedRoute 2Steps 12 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| ROMI-013 | 88158-68-3 | (but-3-yn-1-yloxy)(tert-butyl)diphenylsilane |
| ROMI-014 | 1009301-11-4 | 7-((tert-butyldiphenylsilyl)oxy)-1,1-dimethoxyhept-4-yn-3-one |
| ROMI-015 | - | - |
| ROMI-016 | 1009301-13-6 | (R,E)-7-((tert-butyldiphenylsilyl)oxy)-1,1-dimethoxyhept-4-en-3-ol |
| ROMI-017 | 1009301-15-8 | (R,E)-5-hydroxy-7,7-dimethoxyhept-3-en-1-yl 4-methylbenzenesulfonate |
| ROMI-003 | 180973-42-6 | methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threonyl-L-valinate |
| ROMI-004 | 1009301-28-3 | methyl N-((allyloxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate |
| ROMI-005 | 1009301-19-2 | methyl ((Z)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-006 | 1009301-21-6 | methyl ((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-007 | 180973-32-4 | methyl ((Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-008 | 180973-26-6 | (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid |
| ROMI-009 | 181141-24-2 | methyl ((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-010 | - | (3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone |
| ROMI-011 | 7424-91-1 | methyl 3,3-dimethoxypropanoate |
| ROMI-012 | 1009301-09-0 | N,3,3-trimethoxy-N-methylpropanamide |
OptimisedRoute 3Steps 11 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| ROMI-007 | 180973-32-4 | methyl ((Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-008 | 180973-26-6 | (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid |
| ROMI-009 | 181141-24-2 | methyl ((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate |
| ROMI-018 | 4070-48-8 | (S)-methyl 2-amino-3-methylbutanoate |
| ROMI-019 | 180973-28-8 | methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate |
| ROMI-020 | 180973-30-2 | methyl N-((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate |
| ROMI-021 | 180973-31-3 | methyl N-(N-((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)-S-trityl-D-cysteinyl)-O-tosyl-L-threonyl-L-valinate |
| ROMI-022 | 181141-25-3 | ((Z)-2-((S)-2-((R)-2-((R,E)-3-hydroxy-7-(tritylthio)hept-4-enamido)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine |
| ROMI-023 | - | (3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone |
| ROMI-024 | 1515-75-9 | methyl (E)-penta-2,4-dienoate |
| ROMI-025 | 180973-22-2 | (E)-5-(tritylthio)pent-2-enal |
| ROMI-026 | 81171-44-0 | ((1-(benzyloxy)vinyl)oxy)trimethylsilane |
| ROMI-027 | 180973-41-5 | benzyl (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoate |
OptimisedRoute 4Steps 8 · Total yield 53.6 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| ROMI-008 | 180973-26-6 | (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid |
| ROMI-028 | 1089192-59-5 | - |
| ROMI-029 | 1089192-60-8 | - |
| ROMI-030 | 1089192-61-9 | - |
| ROMI-031 | 1089192-62-0 | - |
| ROMI-032 | 1089192-63-1 | - |
| ROMI-033 | 1089192-64-2 | ((Z)-2-((S)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valine |
| ROMI-034 | 1043577-31-6 | - |
| ROMI-035 | 1089192-65-3 | - |
| ROMI-036 | 663918-95-4 | (S,E)-3-hydroxy-1-((R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-(tritylthio)hept-4-en-1-one |
OptimisedRoute 5Steps 8 · Total yield 30 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| ROMI-019 | 180973-28-8 | methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate |
| ROMI-023 | - | (3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone |
| ROMI-034 | 1043577-31-6 | - |
| ROMI-037 | 167015-11-4 | N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteine |
| ROMI-038 | 1089192-67-5 | methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threoninate |
| ROMI-039 | 1089192-69-7 | methyl (Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoate |
| ROMI-040 | 1089192-70-0 | (5R,8S,Z)-11-ethylidene-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,9-trioxo-8-((tritylthio)methyl)-2-oxa-4,7,10-triazadodecan-12-oic acid |
| ROMI-041 | - | - |
| ROMI-042 | 1089192-65-3 | - |
| ROMI-043 | 68858-20-8 | (((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine |
Frequently asked questions
What are the approved indications of Romidepsin?
Approved indications include: 外周T细胞淋巴瘤, 淋巴瘤.
When does the Romidepsin patent expire?
No public expiry year is available for Romidepsin yet; this page updates once verified.
How many synthesis routes are recorded for Romidepsin?
5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Romidepsin intermediates?
All intermediates in Romidepsin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Romidepsin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24