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CAS 1824037-94-6
Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
Codes：Atorvastatin-123
Application context (from source-drug indications)
高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿托伐他汀锶Atorvastatin strontium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→Acetic acid chloride→(4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one→3-Benzyloxy-1-propanal→(3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid→(4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R)-5-(Benzyloxy)-3-hydroxypentanoic acid→Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate→Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate→(4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one→(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid→Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate
Methyl (3R,5R)-7-amino-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate→5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide→Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate→2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide
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