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CAS 18683-91-5
2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Codes：Ambroxol- 014、Ambroxol- 023
Application context (from source-drug indications)
慢性支气管炎罗红霉素/盐酸氨溴索支气管炎罗红霉素/盐酸氨溴索呼吸道感染罗红霉素/盐酸氨溴索肺炎罗红霉素/盐酸氨溴索气管炎罗红霉素/盐酸氨溴索细菌感染罗红霉素/盐酸氨溴索
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 罗红霉素/盐酸氨溴索Roxithromycin/Ambroxol Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,3-Cyclohexadiene→(1R,4R)-4-Chlorocyclohex-2-en-1-yl acetate→2-(Aminomethyl)-4,6-dibromoaniline→(1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-yl acetate→(1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-ol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Anthranilic acid→Methyl anthranilate→Methyl 2-amino-3,5-dibromobenzoate→2-Amino-3,5-dibromobenzyl alcohol→2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine→2-Amino-3,5-dibromobenzaldehyde→trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol→trans-4-Aminocyclohexanol
3,5-Dibromo-2-nitrobenzaldehyde→trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol→(2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate→o-Nitrobenzaldehyde→trans-4-Aminocyclohexanol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
2-Methylaniline→2,4-Dibromo-6-(bromomethyl)aniline→trans-4-Aminocyclohexanol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide→2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine→trans-4-Aminocyclohexanol→Anthranilic acid N-carboxylic acid anhydride
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