CAS 552-89-6

2-Nitrobenzaldehydeo-Nitrobenzaldehyde

Codes：Ambroxol- 005

Application context (from source-drug indications)

慢性支气管炎罗红霉素/盐酸氨溴索支气管炎罗红霉素/盐酸氨溴索呼吸道感染罗红霉素/盐酸氨溴索肺炎罗红霉素/盐酸氨溴索气管炎罗红霉素/盐酸氨溴索细菌感染罗红霉素/盐酸氨溴索

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
罗红霉素/盐酸氨溴索Roxithromycin/Ambroxol Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

罗红霉素/盐酸氨溴索优化路线steps: 5total yield: 14.7g(Ambroxol)

trans-4-Aminocyclohexanol→2,4-Dihydro-1H-3,1-benzoxazine-2,4-dione→trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide→trans-4-(2-Aminobenzylamino)cyclohexanol→2-Nitrobenzaldehyde→trans-4-(2-Nitrophenylmethyleneamino)cyclohexanol

罗红霉素/盐酸氨溴索优化路线steps: 5total yield: 35.12g(Ambroxol)

3,5-Dibromo-2-nitrobenzaldehyde→trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol→(2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate→o-Nitrobenzaldehyde→trans-4-Aminocyclohexanol→2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

罗红霉素/盐酸氨溴索优化路线steps: 4total yield: 14g(Ambroxol- 005)

o-Nitrotoluene→2-Nitrobenzyl bromide→(2-Nitrophenyl)methanol→[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl→o-Nitrobenzaldehyde

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