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CAS 187223-14-9
1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate
Codes：PASI-014、PASI-016
Application context (from source-drug indications)
库欣综合征门冬氨酸帕瑞肽垂体ACTH分泌过多门冬氨酸帕瑞肽减肥术后低血糖症门冬氨酸帕瑞肽类癌瘤门冬氨酸帕瑞肽神经内分泌瘤门冬氨酸帕瑞肽丛集性头痛门冬氨酸帕瑞肽
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 门冬氨酸帕瑞肽Pasireotide Diaspartate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
PASI-001→PASI-002→PASI-003→PASI-004→PASI-005→(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid→PASI-007→PASI-008→PASI-009→(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-((chlorocarbonyl)oxy)pyrrolidine-1,2-dicarboxylate→tert-butyl (2-aminoethyl)carbamate→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate→(2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid→1-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate→PASI-017→PASI-018→PASI-019→PASI-020→PASI-021→PASI-022→#N/A
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