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CAS 188416-20-8
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride
Codes: VORI-014
Application context (from source-drug indications)
Fungal infectionVoriconazoleCandidaemiaVoriconazoleCandidiasisVoriconazoleAspergillus infectionVoriconazole新型隐球菌感染Voriconazole镰刀菌感染Voriconazole
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Voriconazole | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-chloro-6-ethyl-5-fluoropyrimidine→1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one→2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol→5-fluoropyrimidine→2,4-dichloro-5-fluoropyrimidine→2,4-dichloro-6-ethyl-5-fluoropyrimidine→4-((l5-azanyl)oxy)-2-chloro-6-ethyl-5-fluoropyrimidine→6-ethyl-5-fluoropyrimidin-4-ol→4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine→3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride
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