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CAS 201402-92-8
((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)
Codes: NELF-034
Application context (from source-drug indications)
HIV infectionNelfinavir MesylateMyelofibrosisNelfinavir Mesylate子宫颈功能不全Nelfinavir MesylateSystemic lupus erythematosusNelfinavir MesylateNon-small cell lung cancerNelfinavir Mesylate巨细胞病毒性视网膜炎Nelfinavir Mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Nelfinavir Mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide→(2R,3R)-2,3-dihydroxysuccinic acid→(4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→(2S,3S)-2,3-dihydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→((4R,5R)-2-oxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→sodium (2S,3S)-3-azido-1,4-bis(tosyloxy)butan-2-yl sulfate→(2S,3S)-2-azido-3-hydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→(2S,3S)-3-hydroxy-1,4-bis(tosyloxy)butan-2-aminium chloride→3-(chlorocarbonyl)-2-methylphenyl acetate→3-((S)-4-((S)-1-hydroxy-2-(tosyloxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate
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