CAS 87-69-4

(2R,3R)-2,3-dihydroxysuccinic acid

Codes：ESKE-002、VINF-002

Application context (from source-drug indications)

重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮泌尿系肿瘤酒石酸长春氟宁尿路上皮癌酒石酸长春氟宁乳腺癌酒石酸长春氟宁肺癌酒石酸长春氟宁胃癌酒石酸长春氟宁阴茎癌酒石酸长春氟宁

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸艾司氯胺酮Esketamine Hydrochloride	Tier B — Position early	2029
酒石酸长春氟宁Vinflunine Ditartrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸艾司氯胺酮优化路线steps: 3total yield: 5.09 g (Esketamine Hydrochloride)

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one→(2R,3R)-2,3-dihydroxysuccinic acid→(S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (2R,3R)-2,3-dihydroxysuccinate→(S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one

酒石酸长春氟宁原研路线steps: 2total yield: 1.6 g

methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((6S,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate→(2R,3R)-2,3-dihydroxysuccinic acid

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