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CAS 206997-62-8
(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]
Codes：Clarithromycin-014
Application context (from source-drug indications)
边缘带B细胞淋巴瘤克拉霉素/雷贝拉唑钠/阿莫西林十二指肠溃疡克拉霉素/雷贝拉唑钠/阿莫西林特发性血小板减少性紫癜克拉霉素/雷贝拉唑钠/阿莫西林胃溃疡克拉霉素/雷贝拉唑钠/阿莫西林胃炎克拉霉素/雷贝拉唑钠/阿莫西林幽门螺杆菌感染克拉霉素/雷贝拉唑钠/阿莫西林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 克拉霉素/雷贝拉唑钠/阿莫西林Clarithromycin/Rabeprazole Sodium/Amoxicillin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one→2-Chlorobenzyl chloride→(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]→Acetic acid (2S,3R,4S,6R)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Acetic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]
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