CAS 611-19-8

2-Chlorobenzyl chloride

Codes：Clarithromycin-013、(Ia)91353-6-a、Ticlopidine-002

Application context (from source-drug indications)

边缘带B细胞淋巴瘤克拉霉素/雷贝拉唑钠/阿莫西林十二指肠溃疡克拉霉素/雷贝拉唑钠/阿莫西林特发性血小板减少性紫癜克拉霉素/雷贝拉唑钠/阿莫西林胃溃疡克拉霉素/雷贝拉唑钠/阿莫西林胃炎克拉霉素/雷贝拉唑钠/阿莫西林幽门螺杆菌感染克拉霉素/雷贝拉唑钠/阿莫西林背痛双氯芬酸钠/盐酸乙哌立松动脉闭塞性疾病盐酸噻氯匹定/银杏叶提取物脑血管疾病盐酸噻氯匹定/银杏叶提取物栓塞和血栓形成盐酸噻氯匹定/银杏叶提取物颈动脉狭窄盐酸噻氯匹定/银杏叶提取物

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
克拉霉素/雷贝拉唑钠/阿莫西林Clarithromycin/Rabeprazole Sodium/Amoxicillin	Tier C — Watch / trade	-
双氯芬酸钠/盐酸乙哌立松Diclofenac Sodium/Eperisone Hydrochloride	Tier C — Watch / trade	-
盐酸噻氯匹定/银杏叶提取物Ticlopidine Hydrochloride/Ginkgo Biloba Leaf Dried Extract	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

克拉霉素/雷贝拉唑钠/阿莫西林优化路线steps: 5total yield: 4.2g(Clarithromycin (Free))

(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one→2-Chlorobenzyl chloride→(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]→Acetic acid (2S,3R,4S,6R)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Acetic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester→(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]

双氯芬酸钠/盐酸乙哌立松优化路线steps: 3total yield: /

2-Chlorobenzyl chloride→1-(Bromomethyl)-2-chlorobenzene→Formic acid→(2-Chlorophenyl)acetic acid→1-Chloranyl-2-methylbenzene→2,6-Dichloroaniline→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid

盐酸噻氯匹定/银杏叶提取物优化路线steps: 3total yield: /

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine→2-Chlorobenzyl chloride→thieno[3,2-c]pyridine→5-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridin-5-ium chloride

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