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CAS 209995-38-0
2-(2,4,5-trifluorophenyl)acetic acid
Codes: RETAG-001
Application context (from source-drug indications)
Type 2 diabetesRetagliptin PhosphateDiabetesRetagliptin PhosphateRenal impairmentRetagliptin Phosphate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Retagliptin Phosphate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2,4,5-trifluorophenyl)acetic acid→dimethyl malonate→methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate→(S)-2-amino-2-phenylethanol→(S,E)-methyl 3-((2-hydroxy-1-phenylethyl)amino)-4-(2,4,5-trifluorophenyl)but-2-enoate→(S)-3-phenyl-5-(2,4,5-trifluorobenzyl)-3,4-dihydro-1,4-oxazepin-7(2H)-one→(3S,5R)-3-phenyl-5-(2,4,5-trifluorobenzyl)-1,4-oxazepan-7-one→methyl 3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate→methyl 7-((R)-3-(((S)-2-hydroxy-1-phenylethyl)amino)-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate→methyl 2-amino-2-(pyrazin-2-yl)acetate hydrochloride→2,2,2-trifluoroacetic anhydride→methyl 2-(pyrazin-2-yl)-2-(2,2,2-trifluoroacetamido)acetate→methyl 3-(trifluoromethyl)imidazo[1,5-a]pyrazine-1-carboxylate
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