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CAS 108-59-8
dimethyl malonate
Codes：BRIV-021、NINT-014、PRAL-020
Application context (from source-drug indications)
癫痫部分性发作布瓦西坦癫痫布瓦西坦癫痫发作布瓦西坦系统性硬化相关肺间质疾病乙磺酸尼达尼布特发性肺纤维化乙磺酸尼达尼布非小细胞肺癌乙磺酸尼达尼布肺纤维化乙磺酸尼达尼布间质性肺疾病乙磺酸尼达尼布遗传性出血性毛细血管扩张乙磺酸尼达尼布外周T细胞淋巴瘤普拉曲沙T-细胞淋巴瘤普拉曲沙实体瘤普拉曲沙血液肿瘤普拉曲沙B-细胞淋巴瘤普拉曲沙皮肤T细胞淋巴瘤普拉曲沙
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-aminobutanamide→(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide→pent-1-ene→(R)-pentane-1,2-diol→(4R)-4-propyl-1,3,2-dioxathiolane 2-oxide→(R)-4-propyl-1,3,2-dioxathiolane 2,2-dioxide→dimethyl malonate→(R)-dimethyl 2-propylcyclopropane-1,1-dicarboxylate→(R)-2-propylcyclopropane-1,1-dicarboxylic acid→(R)-6,6-dimethyl-1-propyl-5,7-dioxaspiro[2.5]octane-4,8-dione→(4R)-1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylic acid→1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylic acid→(4R)-methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylate→methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylate→(2S)-2-(2-oxo-5-propylpyrrolidin-1-yl)butanamide
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
methyl 4-formylbenzoate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→methyl (E)-4-(3-oxobut-1-en-1-yl)benzoate→dimethyl malonate→sodium 2,4'-bis(methoxycarbonyl)-5-oxo-1,2,5,6-tetrahydro-[1,1'-biphenyl]-3-olate→5'-hydroxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid→methyl 5'-methoxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 5'-chloro-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→sodium (Z)-4-methoxy-4-oxobut-2-en-2-olate→methyl 5'-(2-methoxy-2-oxoethyl)-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→4-nitrobenzenesulfonohydrazide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | Brivaracetam Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.